Anti-GFAP抗体[GA-5], prediluted (ab9551)

概述

  • 产品名称Anti-GFAP抗体[GA-5], prediluted
    参阅全部 GFAP 一抗
  • 描述
    小鼠单克隆抗体[GA-5] to GFAP, prediluted
  • 特异性This antibody reacts with human GFAP. It shows no cross-reaction with other intermediate filaments. Anti-GFAP stains astrocytes, ependymal cells and corresponding tumors.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Chicken, Dog, Human, Pig
  • 免疫原

    GFAP isolated from porcine spinal cord.

  • 阳性对照
    • Normal brain or astrocytoma
  • 常规说明GFAP is Glial Fibrillary Acidic Protein

性能

应用

Our Abpromise guarantee covers the use of ab9551 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.

This antibody is ready to use. For best results use heat mediated antigen retrieval, this can enhance staining if tissues are over-fixed. Do not use enzymatic mediated antigen retrieval. We recommend incubating sections with the antibody for 30-60 minutes at room temperature.

靶标

  • 功能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
  • 组织特异性Expressed in cells lacking fibronectin.
  • 疾病相关Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰Phosphorylated by PKN1.
  • 细胞定位Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • wu:fb34h11 antibody
    • ALXDRD antibody
    • cb345 antibody
    • etID36982.3 antibody
    • FLJ42474 antibody
    • FLJ45472 antibody
    • GFAP antibody
    • GFAP_HUMAN antibody
    • gfapl antibody
    • Glial fibrillary acidic protein antibody
    • Intermediate filament protein antibody
    • wu:fk42c12 antibody
    • xx:af506734 antibody
    • zgc:110485 antibody
    see all

Anti-GFAP antibody [GA-5], prediluted (ab9551)参考文献

This product has been referenced in:
  • Grace CE  et al. Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice. Neurotoxicol Teratol 32:346-55 (2010). Read more (PubMed: 20096350) »

See 1 Publication for this product

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This product is provided in a pre-diluted, ready-to-use format for immunostaining procedures. There is no need to dilute further this secondary antibody. Please refer to our IHC protocols for more information, and if you have any further questions, ple...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"