概述

  • 产品名称Anti-GFAP抗体
    参阅全部 GFAP 一抗
  • 描述
    兔多克隆抗体to GFAP
  • 特异性ab124657 stains astrocytes, glial cells, ependymal cells and their corresponding tumors. In the peripheral nervous system, it stains Schwann cells, satellite and enteric glial cells. This antibody distinguishes neoplasm of astrocytes origin from other neoplasm of CNS.
  • 经测试应用适用于: IHC-P, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Sheep, Goat, Guinea pig, Cow, Human, Pig
  • 免疫原

    Full length native Human GFAP protein (purified)

  • 阳性对照
    • Human brain or astrocytoma tissue
  • 常规说明ab124657 is prediluted in a proprietry (green colored) buffer.

性能

应用

Our Abpromise guarantee covers the use of ab124657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1.
IHC-Fr 1/1.
ICC 1/1.

靶标

  • 功能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
  • 组织特异性Expressed in cells lacking fibronectin.
  • 疾病相关Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰Phosphorylated by PKN1.
  • 细胞定位Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • wu:fb34h11 antibody
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    • FLJ42474 antibody
    • FLJ45472 antibody
    • GFAP antibody
    • GFAP_HUMAN antibody
    • gfapl antibody
    • Glial fibrillary acidic protein antibody
    • Intermediate filament protein antibody
    • wu:fk42c12 antibody
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    • zgc:110485 antibody
    see all

Anti-GFAP antibody (ab124657)参考文献

ab124657 has not yet been referenced specifically in any publications.

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