概述

  • 产品名称
  • 描述
    兔多克隆抗体to GERP
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 359-408 (QSVPLYPCGV SSSGAEKRKH STAFPEASFL ETSSGPVGGQ YGAAGTASGE) of Human GERP (NP_112174)

  • 阳性对照
    • Placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab86517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 61 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.
  • 组织特异性
    Widely expressed.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the TRIM/RBCC family.
    Contains 2 B box-type zinc fingers.
    Contains 1 RING-type zinc finger.
  • 结构域
    The coiled coil domain is required for homodimerization.
    The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA408830 antibody
    • BB006755 antibody
    • Glioblastoma-expressed RING finger protein antibody
    • Lioblastoma expressed ring finger protein antibody
    • Probable E3 ubiquitin-protein ligase TRIM8 antibody
    • RING finger protein 27 antibody
    • RNF27 antibody
    • RP11-47A8.4 antibody
    • TRIM8 antibody
    • TRIM8_HUMAN antibody
    • Tripartite motif containing 8 antibody
    • Tripartite motif protein TRIM8 antibody
    • Tripartite motif-containing protein 8 antibody
    see all

图片

  • Anti-GERP antibody (ab86517) at 1 µg/ml + Human placenta lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 61 kDa
    Observed band size : 61 kDa
    Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.

实验方案

文献

ab86517 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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