概述

  • 产品名称
  • 描述
    山羊多克隆抗体to GERP
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性

    预测可用于: Mouse, Rat, Dog, Human, Pig
  • 免疫原

    Synthetic peptide: YGQPSTKHYVTS, corresponding to C terminal amino acids 540-551 of Human GERP.

  • 常规说明
    Principal Names – TRIM8; GERP; RNF27; tripartite motif-containing 8; ring finger protein 27; tripartite motif protein TRIM8; glioblastoma expressed ring finger protein. Official Gene Symbol - TRIM8. GenBank Accession Number – NP_112174. LocusLink ID - 81603 (human); 93679 (mouse). Gene Ontology terms - zinc ion binding; molecular function unknown; biological process unknown; kinesin complex; nucleus; cellular component unknown.

性能

应用

Our Abpromise guarantee covers the use of ab4302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Can be blocked with Human GERP peptide (ab23022). No signal obtained yet but low background observed in Human Brain and Human Kidney lysates at up to 1µg / ml.
IHC-P Use a concentration of 4 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.
  • 组织特异性
    Widely expressed.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the TRIM/RBCC family.
    Contains 2 B box-type zinc fingers.
    Contains 1 RING-type zinc finger.
  • 结构域
    The coiled coil domain is required for homodimerization.
    The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA408830 antibody
    • BB006755 antibody
    • Glioblastoma-expressed RING finger protein antibody
    • Lioblastoma expressed ring finger protein antibody
    • Probable E3 ubiquitin-protein ligase TRIM8 antibody
    • RING finger protein 27 antibody
    • RNF27 antibody
    • RP11-47A8.4 antibody
    • TRIM8 antibody
    • TRIM8_HUMAN antibody
    • Tripartite motif containing 8 antibody
    • Tripartite motif protein TRIM8 antibody
    • Tripartite motif-containing protein 8 antibody
    see all

Anti-GERP antibody 图像

  • ab4302 (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Shows preferential nuclear staining in convoluted tubules.

Anti-GERP antibody (ab4302)参考文献

ab4302 has not yet been referenced specifically in any publications.

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