Anti-Germinal Center Kinase抗体(ab38289)

概述

  • 产品名称Anti-Germinal Center Kinase抗体
    参阅全部 Germinal Center Kinase 一抗
  • 描述
    兔多克隆抗体to Germinal Center Kinase
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide (10-30 aa in length) in the region of 302-318 (ELETYDMFPDTIHSRGQ) of human Human Germinal Center Kinase.

  • 阳性对照
    • Mouse skeletal muscle tissue lysate. human hepatocarcinoma
  • 常规说明


    This antibody targets the center part of the protein.

性能

应用

Our Abpromise guarantee covers the use of ab38289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Detects a band of approximately 91 kDa (predicted molecular weight: 91 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/1000.

靶标

  • 功能Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.
  • 组织特异性Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Basolateral cell membrane. Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B lymphocyte serine/threonine protein kinase antibody
    • B lymphocyte serine/threonine-protein kinase antibody
    • BL44 antibody
    • GC kinase antibody
    • GCK antibody
    • Germinal center kinase antibody
    • germinal centre kinase (GC kinase) antibody
    • M4K2_HUMAN antibody
    • Map4k2 antibody
    • MAPK/ERK kinase kinase kinase 2 antibody
    • MEK kinase kinase 2 antibody
    • MEKKK 2 antibody
    • Mitogen activated protein kinase kinase kinase kinase 2 antibody
    • Mitogen-activated protein kinase kinase kinase kinase 2 antibody
    • Rab8 interacting protein antibody
    • Rab8 interacting protein, formerly antibody
    • Rab8-interacting protein antibody
    • RAB8IP antibody
    • RAB8IP, formerly antibody
    see all

Anti-Germinal Center Kinase antibody 图像

  • Anti-Germinal Center Kinase antibody (ab38289) at 1/100 dilution + Mouse skeletal muscle tissue lysate.

    Predicted band size : 91 kDa
    Observed band size : 91 kDa
    Additional bands at : 45 kDa (possible degradation product).
  • 1/50 ab38289 staining human cancer tissue (hepatocarcinoma) by immunohistochemistry - formalin-fixed, paraffin-embedded tissue. The tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-Germinal Center Kinase antibody (ab38289)参考文献

ab38289 has not yet been referenced specifically in any publications.

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