Genistein,蛋白tyrosine kinase抑制剂(ab120112)
Key features and details
- Protein tyrosine kinase inhibitor. Anticancer agent.
- CAS Number: 446-72-0
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Genistein,蛋白tyrosine kinase抑制剂 -
描述
蛋白tyrosine kinase抑制剂. Anticancer agent. -
生物学描述
Phytoestrogen found in soy beans. Anticancer agent. Inihibits tyrosine protein kinase and DNA topoisomerase as well as possessing antioxidant and cell cycle inhibitor activity. Endocytosis inhibitor.
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CAS编号
446-72-0 -
化学结构
性能
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化学名称
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one -
分子量
270.24 -
分子式
C15H10O5 -
PubChem识别号
5280961 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1ccc(cc1)C3=COc2cc(O)cc(O)c2C3=O -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (10)
ab120112 被引用在 10 文献中.
- Mathiesen A et al. Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells. Int J Mol Sci 24:N/A (2023). PubMed: 36674745
- Houdou M et al. Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System. Biomolecules 13:N/A (2023). PubMed: 36830711
- Piepgras J et al. Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide. Front Cell Neurosci 16:860823 (2022). PubMed: 35783090
- Hamouda NN et al. ATP13A3 is a major component of the enigmatic mammalian polyamine transport system. J Biol Chem 296:100182 (2021). PubMed: 33310703
- Martin-Gallausiaux C et al. Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2. Front Immunol 11:583644 (2020). PubMed: 33408714
- van Veen S et al. ATP13A2 deficiency disrupts lysosomal polyamine export. Nature 578:419-424 (2020). PubMed: 31996848
- Sobhy MMK et al. Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection. Exp Parasitol 185:115-123 (2018). PubMed: 29331278
- Ardito F et al. In vitro study on anti-cancer properties of genistein in tongue cancer. Onco Targets Ther 10:5405-5415 (2017). PubMed: 29180873
- Valeri A et al. The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder. Pharmacol Res 66:309-16 (2012). PubMed: 22743170
- Jayagopal A et al. Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells. J Am Chem Soc 132:9789-96 (2010). PubMed: 20586450