概述

  • 产品名称Anti-Gelsolin抗体
    参阅全部 Gelsolin 一抗
  • 描述
    兔多克隆抗体to Gelsolin
  • 经测试应用适用于: WB, IHC-P, ICC, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant Human Gelsolin protein.

  • 阳性对照
    • Human Tonsil tissue; H1299 and Hela whole cell lysates; HeLa cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab113229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 86 kDa.
IHC-P Use a concentration of 10 µg/ml.
ICC 1/100 - 1/200.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
  • 组织特异性Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
  • 疾病相关Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
  • 序列相似性Belongs to the villin/gelsolin family.
    Contains 6 gelsolin-like repeats.
  • 翻译后修饰Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
  • 细胞定位Cytoplasm > cytoskeleton and Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Actin depolymerizing factor antibody
    • Actin-depolymerizing factor antibody
    • ADF antibody
    • AGEL antibody
    • Brevin antibody
    • DKFZp313L0718 antibody
    • GELS_HUMAN antibody
    • Gelsolin antibody
    • Gsn antibody
    see all

Anti-Gelsolin antibody 图像

  • ab113229, at 10µg/ml, staining Gelsolin in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.
  • All lanes : Anti-Gelsolin antibody (ab113229) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 86 kDa
  • ab113229 at 1/200 dilution staining Gelsolin in methanol-fixed HeLa cells by Immunofluorescence. The lower image is co-stained with Hoeschst 33342.

Anti-Gelsolin antibody (ab113229)参考文献

ab113229 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113229.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"