Geldanamycin,Hsp90抑制剂(ab120896)
Key features and details
- Selective Hsp90 inhibitor
- CAS Number: 30562-34-6
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Sterptomyces hygroscopicus
概述
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产品名称
Geldanamycin,Hsp90抑制剂 -
描述
Selective Hsp90抑制剂 -
生物学描述
Selective Hsp90 inhibitor. Binds the ATP site of Hsp90 and inhibits chaperone activity. A benzoquinone ansamycin antibiotic. Also inhibits the Hsp90 paralog GRP94. Exhibits various cellular actions including gene expression, cell proliferation, apoptosis and angiogenesis. -
纯度
> 98% -
CAS编号
30562-34-6 -
化学结构
性能
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化学名称
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate -
分子量
560.64 -
分子式
C29H40N2O9 -
存放说明
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in DMSO to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(C(C=C1N2)=O)=C(C1=O)C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O -
来源
Sterptomyces hygroscopicus
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab120896 被引用在 1 文献中.
- Shabbir A et al. Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury model in vitro. Eur J Neurosci 42:3054-65 (2015). PubMed: 26490753