概述

  • 产品名称Anti-GDNF抗体
    参阅全部 GDNF 一抗
  • 描述
    山羊多克隆抗体to GDNF
  • 特异性GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.
  • 经测试应用适用于: IHC-P, Indirect ELISA, WB, Neutralisingmore details
  • 种属反应性
    与反应: Human, Pig
  • 免疫原

    Recombinant full length human GDNF protein expressed in E. coli.

  • 阳性对照
    • ab10835 has been tested for its ability to neutralize the biological activity of rhGDNF on embryonic chick dorsal root ganglia neurons.

性能

应用

Our Abpromise guarantee covers the use of ab10835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. PubMed: 17540724
Indirect ELISA Use a concentration of 1 µg/ml.
WB Use a concentration of 2 µg/ml. Detects a band of approximately 20 kDa.

GDNF homodimerizes and has 5 isoforms along with a signal and propeptide, so there is a potential for multiple bands in western blot.

Neutralising Use at an assay dependent concentration.

靶标

  • 功能Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
  • 组织特异性In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
  • 疾病相关Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
    Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
  • 序列相似性Belongs to the TGF-beta family. GDNF subfamily.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Astrocyte derived trophic factor antibody
    • Astrocyte derived trophic factor 1 antibody
    • Astrocyte-derived trophic factor antibody
    • ATF 1 antibody
    • ATF 2 antibody
    • Atf antibody
    • ATF1 antibody
    • ATF2 antibody
    • gdnf antibody
    • GDNF_HUMAN antibody
    • Glial cell derived neurotrophic factor antibody
    • Glial Cell Line Derived Neurotrophic Factor antibody
    • Glial cell line-derived neurotrophic factor antibody
    • Glial derived neurotrophic factor antibody
    • HFB1 GDNF antibody
    • hGDNF antibody
    • HSCR3 antibody
    see all

Anti-GDNF antibody (ab10835)参考文献

This product has been referenced in:
  • Linher K  et al. Glial cell line-derived neurotrophic factor: an intraovarian factor that enhances oocyte developmental competence in vitro. Endocrinology 148:4292-301 (2007). IHC-P ; Pig . Read more (PubMed: 17540724) »

See 1 Publication for this product

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