概述

  • 产品名称Anti-GDF1抗体[EPR5815]
    参阅全部 GDF1 一抗
  • 描述
    兔单克隆抗体[EPR5815] to GDF1
  • 经测试应用适用于: WB, IPmore details
    不适用于: Flow Cyt,ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human GDF1 protein (P27539).

  • 阳性对照
    • U87-MG and Human fetal brain lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab124706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 39 kDa.
IP 1/10 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
  • 靶标

    • 功能May mediate cell differentiation events during embryonic development.
    • 组织特异性Expressed in the brain.
    • 疾病相关Defects in GDF1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.
      Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3) [MIM:613854]. A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries.
      Defects in GDF1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
    • 序列相似性Belongs to the TGF-beta family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DORV antibody
      • DTGA3 antibody
      • Embryonic growth/differentiation factor 1 antibody
      • GDF 1 antibody
      • GDF-1 antibody
      • GDF1 antibody
      • GDF1_HUMAN antibody
      • Growth differentiation factor 1 antibody
      see all

    Anti-GDF1 antibody [EPR5815] 图像

    • All lanes : Anti-GDF1 antibody [EPR5815] (ab124706) at 1/1000 dilution

      Lane 1 : U87-MG cell lysate
      Lane 2 : Human fetal brain lysates cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 39 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-GDF1 antibody [EPR5815] (ab124706)参考文献

    This product has been referenced in:
    • Ginkel C  et al. Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem 287:41888-902 (2012). WB ; Mouse . Read more (PubMed: 23074226) »

    See 1 Publication for this product

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