概述

  • 产品名称Anti-GCET2抗体
    参阅全部 GCET2 一抗
  • 描述
    小鼠单克隆抗体to GCET2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length human GCET2 protein (AAH30506) with a proprietary tag.

  • 阳性对照
    • Jurkat cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab89180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 21 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
  • 组织特异性Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
  • 翻译后修饰Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
  • 细胞定位Cytoplasm. Cell membrane. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GCAT2 antibody
    • Gcet antibody
    • GCET2 germinal center expressed transcript 2 antibody
    • GCET2 germinal centre expressed transcript 2 antibody
    • Gcsam antibody
    • GCSAM_HUMAN antibody
    • Germinal center associated lymphoma antibody
    • Germinal center associated lymphoma protein antibody
    • Germinal center B cell associated protein 2 antibody
    • Germinal center B-cell-expressed transcript 2 protein antibody
    • Germinal center expressed transcript 2 antibody
    • Germinal center-associated lymphoma protein antibody
    • Germinal center-associated signaling and motility protein antibody
    • Germinal centre associated lymphoma antibody
    • Germinal centre associated lymphoma protein antibody
    • Germinal centre B cell associated protein 2 antibody
    • Germinal centre expressed transcript 2 antibody
    • hGAL antibody
    • M17 antibody
    • M17 L antibody
    see all

Anti-GCET2 antibody 图像

Anti-GCET2 antibody (ab89180)参考文献

ab89180 has not yet been referenced specifically in any publications.

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