概述

  • 产品名称Anti-GATM抗体
    参阅全部 GATM 一抗
  • 描述
    小鼠多克隆抗体to GATM
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human GATM protein

  • 阳性对照
    • Transfected 293T cell lysate; human liver tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab67713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.

靶标

  • 功能Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
  • 组织特异性Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
  • 通路Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.
  • 疾病相关Defects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency) [MIM:612718]. AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain.
  • 序列相似性Belongs to the amidinotransferase family.
  • 结构域One chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site.
  • 细胞定位Mitochondrion inner membrane. Cytoplasm. The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AGAT antibody
    • AT antibody
    • GATM antibody
    • GATM_HUMAN antibody
    • Glycine amidinotransferase antibody
    • Glycine amidinotransferase, mitochondrial antibody
    • L-arginine:glycine amidinotransferase antibody
    • mitochondrial antibody
    • Transamidinase antibody
    see all

Anti-GATM antibody 图像

  • Anti-GATM antibody (ab67713) at 1/500 dilution + human liver at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • All lanes : Anti-GATM antibody (ab67713) at 1/500 dilution

    Lane 1 : GATM transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
    Additional bands at : 50 kDa. We are unsure as to the identity of these extra bands.

Anti-GATM antibody (ab67713)参考文献

ab67713 has not yet been referenced specifically in any publications.

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