Anti-GATA3抗体(ab106625)
Key features and details
- Rabbit polyclonal to GATA3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GATA3抗体
参阅全部 GATA3 一抗 -
描述
兔多克隆抗体to GATA3 -
宿主
Rabbit -
特异性
At least two isoforms of GATA3 are known to exist; ab106625 will recognize both isoforms. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human GATA3 (C terminal).
Database link: P23771 -
阳性对照
- WB: Human brain tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106625于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB | (1) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 48 kDa.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 48 kDa. |
靶标
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功能
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. -
组织特异性
T-cells and endothelial cells. -
疾病相关
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome. -
序列相似性
Contains 2 GATA-type zinc fingers. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 2625 Human
- Omim: 131320 Human
- SwissProt: P23771 Human
- Unigene: 524134 Human
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形式
There are 2 isoforms produced by alternative splicing. -
别名
- GATA 3 antibody
- GATA binding factor 3 antibody
- GATA binding protein 3 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (27)
ab106625 被引用在 27 文献中.
- Tu J et al. MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes. Mol Ther Nucleic Acids 27:733-750 (2022). PubMed: 35317281
- Broome R et al. TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Rep 34:108776 (2021). PubMed: 33626359
- Yue-Chun L et al. Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis. Virulence 12:360-376 (2021). PubMed: 33380272
- Pang L et al. Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice. Mol Med Rep 23:N/A (2021). PubMed: 33760131
- Lu N et al. miRNA-490-3p promotes the metastatic progression of invasive ductal carcinoma. Oncol Rep 45:706-716 (2021). PubMed: 33416185