Anti-Gastrin抗体(Biotin) (ab48283)

概述

• 产品名称
  Anti-Gastrin抗体(Biotin)
  参阅全部 Gastrin 一抗
• 描述
  兔多克隆抗体to Gastrin (Biotin)
• 偶联物
  Biotin
• 经测试应用
  适用于: ELISA, IP, RIAmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Sheep, Goat, Horse, Guinea pig, Cow, Cat, Dog, Pig, Rhesus monkey
• 免疫原

  Synthetic peptide: QGPWLEEEEEAYGWMDF-NH₂ conjugated to KLH via carboxyl group, corresponding to amino acids 76-92 of Human Gastrin.

  Run BLAST with Run BLAST with

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 50% Glycerol, PBS, pH 7.5
• Concentration information loading...
• 纯度
  Protein G purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cardiovascular
  • Blood
  • Other

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cancer
  • Tumor biomarkers
  • Hormones

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Leukocyte recruitment
  • Other

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
• 序列相似性
  Belongs to the gastrin/cholecystokinin family.
• 翻译后修饰
  Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
  Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P01350 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 280800 Cow
  • Entrez Gene: 2520 Human
  • Entrez Gene: 14459 Mouse
  • Entrez Gene: 445524 Pig
  • Omim: 137250 Human
  • SwissProt: P01354 Cat
  • SwissProt: P01352 Cow
  • SwissProt: P01353 Dog

  • SwissProt: P04564 Goat
  • SwissProt: P06885 Guinea pig
  • SwissProt: P55885 Horse
  • SwissProt: P01350 Human
  • SwissProt: P48757 Mouse
  • SwissProt: P01351 Pig
  • SwissProt: O02686 Sheep
  • Unigene: 312 Cow
  • Unigene: 2681 Human
  • Unigene: 644 Pig

  see all
• 别名
  • Component II antibody
  • G14 antibody
  • G17 antibody

  • G34 antibody
  • G52 antibody
  • G6 antibody
  • GAS antibody
  • Gast antibody
  • GAST_HUMAN antibody
  • Gastrin antibody
  • Gastrin component I antibody
  • Gastrin component II antibody
  • Gastrin component III antibody
  • Gastrin precursor antibody
  • Gastrin-14 antibody
  • Gastrin-17 antibody
  • Gastrin-34 antibody
  • Gastrin-52 antibody
  • Gastrin-6 antibody
  • Gastrin-71 antibody

  see all

实验方案

• Immunoprecipitation protocols