概述

  • 产品名称Anti-Gastrin抗体
    参阅全部 Gastrin 一抗
  • 描述
    兔多克隆抗体to Gastrin
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Dog
  • 免疫原

    Synthetic peptide:

    MQRLCVYVLIFAL

    conjugated to BSA, corresponding to N terminal amino acids 1-13 of Human Gastrin.

  • 阳性对照
    • Pituitary or stomach
  • 常规说明


    This antibody may be used to study the differential tissue expression and intracellular and subcellular localization of gastrin in neuroendocrine cells of the gastrointestinal tract,and in the CNS. Antibodies to gastrin are also useful for the identificationand detection of gastrin in normal and neoplastic tissue.

性能

应用

Our Abpromise guarantee covers the use of ab16035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/200.

靶标

  • 功能Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • 序列相似性Belongs to the gastrin/cholecystokinin family.
  • 翻译后修饰Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Component II antibody
    • G14 antibody
    • G17 antibody
    • G34 antibody
    • G52 antibody
    • G6 antibody
    • GAS antibody
    • Gast antibody
    • GAST_HUMAN antibody
    • Gastrin antibody
    • Gastrin component I antibody
    • Gastrin component II antibody
    • Gastrin component III antibody
    • Gastrin precursor antibody
    • Gastrin-14 antibody
    • Gastrin-17 antibody
    • Gastrin-34 antibody
    • Gastrin-52 antibody
    • Gastrin-6 antibody
    • Gastrin-71 antibody
    see all

Anti-Gastrin antibody 图像

  • ab16035 staining human Gastrin at 1/200 dilution in stomach by Immunohistochemistry (FFPE-sections).

Anti-Gastrin antibody (ab16035)参考文献

This product has been referenced in:
  • Lennerz JK  et al. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. Am J Pathol 177:1514-33 (2010). IHC-P ; Human . Read more (PubMed: 20709804) »

See 1 Publication for this product

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We do not have any experimental data regarding the cross-reactivity of ab16035 with CCK. I compared the immunogen sequence for ab16035 with that of the CCK sequence (P06307-Uniprot) and the percentage homology is ...

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Thank you for contacting us.

We have not experimentally tested the possibility of ab16035 cross reactivity with CCK. So I am sorry we cannot confirm it 100%. The recommendations we gave were based on the minimal sequence homology between CCK...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"