Anti-Gasdermin like抗体(ab57438)

概述

  • 产品名称Anti-Gasdermin like抗体
    参阅全部 Gasdermin like 一抗
  • 描述
    小鼠单克隆抗体to Gasdermin like
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-412 of Human Gasdermin like

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57438 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.
    • 组织特异性In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
    • 序列相似性Belongs to the gasdermin family.
    • 结构域Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
    • 细胞定位Cytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
    • Information by UniProt
    • 数据库链接
    • 形式There are 5 isoforms produced by alternative splicing.
    • 别名
      • 123 antibody
      • 156 antibody
      • Gasdermin B antibody
      • Gasdermin like protein antibody
      • Gasdermin-B antibody
      • Gasdermin-like protein antibody
      • GSDMB antibody
      • GSDMB_HUMAN antibody
      • GSDML antibody
      • PP4052 antibody
      • PRO2521 antibody
      see all

    Anti-Gasdermin like antibody 图像



    • Predicted band size : 47 kDa
      Gasdermin like antibody (ab57438) at 1ug/lane + Jurkat cell lysate at 25ug/lane.

    Anti-Gasdermin like antibody (ab57438)参考文献

    ab57438 has not yet been referenced specifically in any publications.

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