Anti-Gasdermin like抗体(ab103980)

概述

  • 产品名称Anti-Gasdermin like抗体
    参阅全部 Gasdermin like 一抗
  • 描述
    兔多克隆抗体to Gasdermin like
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 21-194 of Human Gasdermin like (AAH25682).

  • 阳性对照
    • HeLa whole cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab103980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.

靶标

  • 功能The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.
  • 组织特异性In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
  • 序列相似性Belongs to the gasdermin family.
  • 结构域Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
  • 细胞定位Cytoplasm. Cytoplasm, cytosol. Cell membrane. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
  • Information by UniProt
  • 数据库链接
  • 形式There are 5 isoforms produced by alternative splicing.
  • 别名
    • 123 antibody
    • 156 antibody
    • Gasdermin B antibody
    • Gasdermin like protein antibody
    • Gasdermin-B antibody
    • Gasdermin-like protein antibody
    • GSDMB antibody
    • GSDMB_HUMAN antibody
    • GSDML antibody
    • PP4052 antibody
    • PRO2521 antibody
    see all

Anti-Gasdermin like antibody 图像

  • Anti-Gasdermin like antibody (ab103980) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 47 kDa

Anti-Gasdermin like antibody (ab103980)参考文献

ab103980 has not yet been referenced specifically in any publications.

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