Anti-GAPDH抗体[6C5] (FITC) (ab105430)

概述

  • 产品名称Anti-GAPDH抗体[6C5] (FITC)
    参阅全部 GAPDH 一抗
  • 描述
    小鼠单克隆抗体[6C5] to GAPDH (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 经测试应用适用于: ICC, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Cat, Dog, Human, Pig, Fish
  • 免疫原

    Rabbit GAPDH

  • 常规说明Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with rabbit GAPDH.

应用

Our Abpromise guarantee covers the use of ab105430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 36 kDa.

靶标

  • 功能Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.
  • 通路Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.
  • 序列相似性Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  • 翻译后修饰S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus.
    ISGylated.
  • 细胞定位Cytoplasm > cytosol. Nucleus. Cytoplasm > perinuclear region. Membrane. Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions.
  • Information by UniProt
  • 数据库链接
  • 别名
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Anti-GAPDH antibody [6C5] (FITC) (ab105430)参考文献

ab105430 has not yet been referenced specifically in any publications.

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