Anti-Ganglioside GD2抗体[2Q549] (ab68456)

概述

  • 产品名称Anti-Ganglioside GD2抗体[2Q549]
    参阅全部 Ganglioside GD2 一抗
  • 描述
    小鼠单克隆抗体[2Q549] to Ganglioside GD2
  • 经测试应用适用于: ICC, IHC-Fr, Flow Cyt, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Disialoganglioside GD2

性能

应用

Our Abpromise guarantee covers the use of ab68456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use 1-2µg for 106 cells. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

靶标

  • 相关性Gangliosides are a group of galactose-containing cerebrosides found in the surface membranes of nerve cells. Ganglioside GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. GD2 is a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors due to its relatively tumor specific expression.
  • 别名
    • Disialoganglioside GD2 antibody

Anti-Ganglioside GD2 antibody [2Q549] (ab68456)参考文献

This product has been referenced in:
  • Tarek N  et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest 122:3260-70 (2012). Read more (PubMed: 22863621) »
  • Battula VL  et al. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest 122:2066-78 (2012). Flow Cyt ; Human . Read more (PubMed: 22585577) »

See all 2 Publications for this product

Product Wall

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Es importante que todos los anticuerpos que escojas para llevar a cabo IHC-P en tejido humano estén validados (y por tanto garantizados por Abcam) para funcionar en esta especie y aplicación. Est...

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Thank you for contacting Abcam.  For ab68456 the Ganglioside GD2 antibody, was produced against a human neuroblastoma cell line.  We don't have any more specific information on this immunogen.  I am sorry that I cannot provide any more information but ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"