Anti-Ganglioside GD2抗体[14.G2a] (ab68456)
Key features and details
- Mouse monoclonal [14.G2a] to Ganglioside GD2
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG2a
概述
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产品名称
Anti-Ganglioside GD2抗体[14.G2a]
参阅全部 Ganglioside GD2 一抗 -
描述
小鼠单克隆抗体[14.G2a] to Ganglioside GD2 -
宿主
Mouse -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human Ganglioside GD2. Neuroblastoma cell line LAN-1
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常规说明
This product was changed from ascites to tissue culture supernatant on 30/Aug/19. Lot numbers higher than GR3295317 are from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1.45% Sodium chloride -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
14.G2a -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab68456于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF | (1) |
Use at an assay dependent concentration.
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说明 |
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ICC/IF
Use at an assay dependent concentration. |
靶标
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相关性
Gangliosides are a group of galactose-containing cerebrosides found in the surface membranes of nerve cells. Ganglioside GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. GD2 is a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors due to its relatively tumor specific expression. -
别名
- Disialoganglioside GD2 antibody
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab68456 被引用在 9 文献中.
- Wang H et al. Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway. Onco Targets Ther 13:3903-3920 (2020). PubMed: 32440155
- Lamotte JD et al. hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins. Front Pharmacol 11:617867 (2020). PubMed: 33519485
- Tsujimoto T et al. An acellular bioresorbable ultra-purified alginate gel promotes intervertebral disc repair: A preclinical proof-of-concept study. EBioMedicine 37:521-534 (2018). PubMed: 30389504
- Dewald JH et al. TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines. PLoS One 13:e0196369 (2018). PubMed: 29698439
- Feng X et al. Expression of EMT markers and mode of surgery are prognostic in phyllodes tumors of the breast. Oncotarget 8:33365-33374 (2017). PubMed: 28380418
- Orsi G et al. GD2 expression in breast cancer. Oncotarget 8:31592-31600 (2017). IHC-P ; Human . PubMed: 28415563
- Matarrese P et al. Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation. Autophagy 10:750-65 (2014). PubMed: 24589479
- Tarek N et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest 122:3260-70 (2012). PubMed: 22863621
- Battula VL et al. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest 122:2066-78 (2012). Flow Cyt ; Human . PubMed: 22585577