概述

  • 产品名称
    Anti-gamma Synuclein抗体
    参阅全部 gamma Synuclein 一抗
  • 描述
    羊多克隆抗体to gamma Synuclein
  • 特异性
    The peptide sequence was chosen to achieve a high level of specificity in the antiserum. Specificity also has been demonstrated by immunohistochemistry and western blot.
  • 经测试应用
    适用于: WB, ELISA, IHC-Frmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide:

    EKEEVAEEAQSGGD

    , corresponding to C terminal amino acids 114-127 of Human gamma Synuclein. This peptide was conjugated to carrier protein to enhance the immunological response.

性能

应用

Our Abpromise guarantee covers the use of ab49206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 3 µg/ml. Predicted molecular weight: 13 kDa.
ELISA Use a concentration of 1 µg/ml.
IHC-Fr Use a concentration of 3 - 5 µg/ml.

靶标

  • 功能
    Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
  • 组织特异性
    Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
  • 序列相似性
    Belongs to the synuclein family.
  • 翻译后修饰
    Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
  • 细胞定位
    Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BCSG1 antibody
    • Breast cancer specific gene 1 protein antibody
    • Breast cancer specific protein 1 antibody
    • Breast cancer-specific gene 1 protein antibody
    • Gamma synuclein antibody
    • Gamma-synuclein antibody
    • Persyn antibody
    • PRSN antibody
    • SNCG antibody
    • SR antibody
    • Synoretin antibody
    • Synuclein gamma antibody
    • synuclein, gamma (breast cancer-specific protein 1) antibody
    • SYUG_HUMAN antibody
    see all

文献

This product has been referenced in:
  • Wilding C  et al. ?-Synuclein antibodies have neuroprotective potential on neuroretinal cells via proteins of the mitochondrial apoptosis pathway. PLoS One 9:e90737 (2014). Read more (PubMed: 24595072) »

See 1 Publication for this product

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