Anti-gamma Catenin抗体[M354] (ab119772)

概述

  • 产品名称Anti-gamma Catenin抗体[M354]
    参阅全部 gamma Catenin 一抗
  • 描述
    小鼠单克隆抗体[M354] to gamma Catenin
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 275-285 of Human gamma Catenin.

  • 阳性对照
    • A431 cells and cell lysate; HUVEC cell lysate.
  • 常规说明Do not aliquot.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab119772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 82 kDa).
ICC 1/100.

靶标

  • 功能Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • 疾病相关Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
    Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性Belongs to the beta-catenin family.
    Contains 9 ARM repeats.
  • 细胞定位Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVD 12 antibody
    • ARVD12 antibody
    • Catenin (cadherin associated protein), gamma 80kDa antibody
    • catenin (cadherin-associated protein) gamma (80kD) antibody
    • Catenin gamma antibody
    • CTNNG antibody
    • Desmoplakin 3 antibody
    • Desmoplakin III antibody
    • Desmoplakin-3 antibody
    • Desmoplakin3 antibody
    • DesmoplakinIII antibody
    • DP 3 antibody
    • DP III antibody
    • DP3 antibody
    • DPIII antibody
    • gamma catenin antibody
    • Junction plakoglobin antibody
    • JUP antibody
    • OTTHUMP00000164732 antibody
    • OTTHUMP00000164735 antibody
    • OTTHUMP00000164738 antibody
    • PDGB antibody
    • PKGB antibody
    • PLAK_HUMAN antibody
    • PLAKOGLOBIN antibody
    see all

Anti-gamma Catenin antibody [M354] 图像

  • Lanes 1 - 2 : Anti-gamma Catenin antibody [M354] (ab119772) at 1/1000 dilution
    Lanes 3 - 4 : Anti-gamma Catenin (T916) rabbit polyclonal at 1/1000 dilution

    Lane 1 : A431 cells stimulated with calyculin A (100 nM) for 30 min
    Lane 2 : A431 cells stimulated with calyculin A (100 nM) for 30 min and treated with lambda phosphatase
    Lane 3 : A431 cells stimulated with calyculin A (100 nM) for 30 min
    Lane 4 : A431 cells stimulated with calyculin A (100 nM) for 30 min and treated with lambda phosphatase


    Predicted band size : 82 kDa
  • ab119772 at 1/100 dilution staining gamma Catenin in untreated (Top) or pervanadate treated (bottom) A431 cells. Detection using donkey anti-mouse secondary conjugated to Cy3.

Anti-gamma Catenin antibody [M354] (ab119772)参考文献

ab119772 has not yet been referenced specifically in any publications.

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