概述

  • 产品名称Anti-gamma Catenin抗体
    参阅全部 gamma Catenin 一抗
  • 描述
    山羊多克隆抗体to gamma Catenin
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: GLRPPYPTADHMLA, corresponding to amino acids 730-743 of Human Plakoglobin.

  • 阳性对照
    • A431 lysate.

性能

应用

Our Abpromise guarantee covers the use of ab11799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/32000. This antibody may be sensitive to freeze/thaw cycles in this assay
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 86 kDa).Can be blocked with Human gamma Catenin peptide (ab23208).

靶标

  • 功能Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • 疾病相关Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
    Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性Belongs to the beta-catenin family.
    Contains 9 ARM repeats.
  • 细胞定位Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARVD 12 antibody
    • ARVD12 antibody
    • Catenin (cadherin associated protein), gamma 80kDa antibody
    • catenin (cadherin-associated protein) gamma (80kD) antibody
    • Catenin gamma antibody
    • CTNNG antibody
    • Desmoplakin 3 antibody
    • Desmoplakin III antibody
    • Desmoplakin-3 antibody
    • Desmoplakin3 antibody
    • DesmoplakinIII antibody
    • DP 3 antibody
    • DP III antibody
    • DP3 antibody
    • DPIII antibody
    • gamma catenin antibody
    • Junction plakoglobin antibody
    • JUP antibody
    • OTTHUMP00000164732 antibody
    • OTTHUMP00000164735 antibody
    • OTTHUMP00000164738 antibody
    • PDGB antibody
    • PKGB antibody
    • PLAK_HUMAN antibody
    • PLAKOGLOBIN antibody
    see all

Anti-gamma Catenin antibody 图像

  • Anti-gamma Catenin antibody (ab11799) at 1 µg/ml + Rat eye lysate at 35 µg

    Predicted band size : 86 kDa
  • Anti-gamma Catenin antibody (ab11799) at 0.0299999993294 µg/ml + A431 cell lysate at 35 µg

    Predicted band size : 86 kDa

Anti-gamma Catenin antibody (ab11799)参考文献

This product has been referenced in:
  • Shair KH  et al. EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res 68:6997-7005 (2008). WB ; Human . Read more (PubMed: 18757414) »
  • Mainou BA  et al. Unique signaling properties of CTAR1 in LMP1-mediated transformation. J Virol 81:9680-92 (2007). WB ; Rat . Read more (PubMed: 17626074) »

See all 2 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Nasopharyngeal carcinoma cell line)
Loading amount 10 µg
Specification Nasopharyngeal carcinoma cell line
Gel Running Conditions Reduced Denaturing (8%)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
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提交于 Jun 22 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"