概述

  • 产品名称Anti-GALNT8抗体
  • 描述
    兔多克隆抗体to GALNT8
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 502-629 of Human GALNT8 (Q9NY28).

  • 阳性对照
    • Human small intestine tissues; RT4, U251 MG, Human liver and Human tonsil lysates.

性能

应用

Our Abpromise guarantee covers the use of ab121374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

靶标

  • 功能Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
  • 组织特异性Widely expressed. Expressed in heart, skeletal muscle, kidney, liver, small intestine and placenta. Weakly expressed in colon, thymus, spleen, lung and leukocyte.
  • 通路Protein modification; protein glycosylation.
  • 序列相似性Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • 结构域There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • 细胞定位Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GALNAC T8 antibody
    • GalNAc-T8 antibody
    • GALNT8 antibody
    • GALT8_HUMAN antibody
    • Polypeptide GalNAc transferase 8 antibody
    • pp-GaNTase 8 antibody
    • Probable polypeptide N-acetylgalactosaminyltransferase 8 antibody
    • Protein-UDP acetylgalactosaminyltransferase 8 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8 antibody
    see all

Anti-GALNT8 antibody 图像

  • ab121374 at 1/75 dilution staining GALNT8 in Paraffin-embedded Human Small intestine tissue by Immunohistochemistry.
  • All lanes : Anti-GALNT8 antibody (ab121374) at 1/250 dilution

    Lane 1 : RT4 lysate
    Lane 2 : U251 MG lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

Anti-GALNT8 antibody (ab121374)参考文献

ab121374 has not yet been referenced specifically in any publications.

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