概述

  • 产品名称Anti-GALNT12抗体
    参阅全部 GALNT12 一抗
  • 描述
    兔多克隆抗体to GALNT12
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within internal sequence amino acids 34-173 of Human GALNT12 (AAH13945; UniProt ID: Q8IXK2 isoform 2).

  • 阳性对照
    • A549 whole cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab101358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: for isoform 2, 32 kDa.

靶标

  • 功能Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
  • 组织特异性Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate.
  • 通路Protein modification; protein glycosylation.
  • 疾病相关Defects in GALNT12 are a cause of susceptibility to colorectal cancer type 1 (CRCS1) [MIM:608812]. Colorectal cancer is a malignancy originating either in the colon or rectum or both.
  • 序列相似性Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • 结构域There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • 细胞定位Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Colorectal cancer susceptibility to 1 antibody
    • CRCS1 antibody
    • FLJ21212 antibody
    • GalNAc T12 antibody
    • GalNAc-T12 antibody
    • GalNAcT12 antibody
    • GALNT 12 antibody
    • Galnt12 antibody
    • GLT12_HUMAN antibody
    • Polypeptide GalNAc transferase 12 antibody
    • Polypeptide N acetylgalactosaminyltransferase 12 antibody
    • Polypeptide N-acetylgalactosaminyltransferase 12 antibody
    • pp GaNTase 12 antibody
    • pp-GaNTase 12 antibody
    • Protein UDP acetylgalactosaminyltransferase 12 antibody
    • Protein-UDP acetylgalactosaminyltransferase 12 antibody
    • UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12 antibody
    • UDP GalNAc polypeptide N acetylgalactosaminyltransferase antibody
    • UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12 antibody
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 antibody
    see all

Anti-GALNT12 antibody 图像

  • Anti-GALNT12 antibody (ab101358) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : for isoform 2, 32 kDa

Anti-GALNT12 antibody (ab101358)参考文献

ab101358 has not yet been referenced specifically in any publications.

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