概述

  • 产品名称Anti-GALE抗体
    参阅全部 GALE 一抗
  • 描述
    小鼠多克隆抗体to GALE
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length GALE protein (Human)

  • 阳性对照
    • Human colon tissue lysate. GALE transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab67389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).

靶标

  • 功能Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
  • 通路Carbohydrate metabolism; galactose metabolism.
  • 疾病相关Defects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
  • 序列相似性Belongs to the sugar epimerase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ95174 antibody
    • FLJ97302 antibody
    • Galactose 4 epimerase UDP antibody
    • Galactowaldenase antibody
    • galE antibody
    • GALE_HUMAN antibody
    • OTTHUMP00000002991 antibody
    • OTTHUMP00000002994 antibody
    • OTTHUMP00000037931 antibody
    • OTTHUMP00000044857 antibody
    • SDR1E1 antibody
    • short chain dehydrogenase/reductase family 1E member 1 antibody
    • UDP galactose 4 epimerase antibody
    • UDP galactose 4' epimerase antibody
    • UDP glucose 4 epimerase antibody
    • UDP-galactose 4-epimerase antibody
    • UDP-glucose 4-epimerase antibody
    see all

Anti-GALE antibody 图像

  • Anti-GALE antibody (ab67389) at 1/500 dilution + Human colon tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa
  • All lanes : Anti-GALE antibody (ab67389) at 1/500 dilution

    Lane 1 : GALE transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

Anti-GALE antibody (ab67389)参考文献

This product has been referenced in:
  • Deng Y  et al. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest 123:455-68 (2013). WB ; Mouse . Read more (PubMed: 23257357) »

See 1 Publication for this product

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