Anti-GADD34抗体(ab125464)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to GADD34
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 116-165 (GMYGEREATS VPRGQGSQFA DGQRAPLSPS LLIRTLQGSD KNPGEEKAEE) of the Human GADD34 protein (NP_055145).

  • 阳性对照
    • Human fetal heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125464 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
  • 序列相似性
    Belongs to the PPP1R15 family.
  • 翻译后修饰
    Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity.
  • 细胞定位
    Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apoptosis associated protein antibody
    • GADD 34 antibody
    • Growth arrest and DNA damage inducible 34 antibody
    • Growth arrest and DNA damage-inducible protein GADD34 antibody
    • Myeloid differentiation primary response protein MyD116 homolog antibody
    • Ppp1r15a antibody
    • PR15A_HUMAN antibody
    • Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody
    • Protein phosphatase 1 regulatory subunit 15A antibody
    see all

Anti-GADD34 antibody 图像

  • Anti-GADD34 antibody (ab125464) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 73 kDa

实验方案

Anti-GADD34 antibody (ab125464)参考文献

ab125464 has not yet been referenced specifically in any publications.

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Thank you for providing that information.
Based on all of the data that you have sent, I do not believe that there are any protocol variations that I can suggest that will help to resolve this issue. Therefore i would be happy to replace or refund...

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Thank you for contacting Abcam.
The antibody is covered under our Abpromise for six months and is guaranteed to work in western blot on human samples . If we cannot resolve the issue you are having with the antibody then I would be happy to either...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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