Anti-GABA B Receptor 2 (phospho S884)抗体[EP2317Y] (ab68425)


  • 产品名称Anti-GABA B Receptor 2 (phospho S884)抗体[EP2317Y]
    参阅全部 GABA B Receptor 2 一抗
  • 描述
    兔单克隆抗体[EP2317Y] to GABA B Receptor 2 (phospho S884)
  • 特异性Detectes GABA B Receptor 2 only when phosphorylated at serine 884
  • 经测试应用适用于: WB, IP, ICC/IFmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic phosphopeptide corresponding to residues surrounding serine 884 of Human GABA B Receptor 2.

  • 阳性对照
    • Brain
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab68425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2500 - 1/5000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
IP 1/30.
ICC/IF 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt or IHC-P.
  • 靶标

    • 功能Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
    • 组织特异性Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
    • 序列相似性Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
    • 结构域Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
    • 细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
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    Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] 图像

    • All lanes : Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] (ab68425) at 1/5000 dilution

      Lane 1 : Untreated Human brain lysate
      Lane 2 : AP-treated Human brain lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled Goat anti-Rabbit at 1/2000 dilution

      Predicted band size : 106 kDa
      Observed band size : 106 kDa

    Anti-GABA B Receptor 2 (phospho S884) antibody [EP2317Y] (ab68425)参考文献

    ab68425 has not yet been referenced specifically in any publications.

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