重组Anti-GABA B Receptor 2/GABBR2 (phospho S884)抗体[EP2317Y] (ab68425)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EP2317Y] to GABA B Receptor 2/GABBR2 (phospho S884)
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-GABA B Receptor 2/GABBR2 (phospho S884)抗体[EP2317Y]
参阅全部 GABA B Receptor 2/GABBR2 一抗 -
描述
兔单克隆抗体[EP2317Y] to GABA B Receptor 2/GABBR2 (phospho S884) -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF or IHC-P -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Brain
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.31% Sodium citrate, 0.175% Sodium chloride, 0.0172% EDTA, 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EP2317Y -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab68425于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/2500 - 1/5000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
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说明 |
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WB
1/2500 - 1/5000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa). |
靶标
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功能
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. -
组织特异性
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. -
序列相似性
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. -
结构域
Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1. -
细胞定位
Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9568 Human
- Entrez Gene: 242425 Mouse
- Omim: 607340 Human
- SwissProt: O75899 Human
- SwissProt: Q80T41 Mouse
- Unigene: 198612 Human
- Unigene: 101909 Mouse
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别名
- BcDNA:GH07312 antibody
- CG6706 antibody
- CT20836 antibody
see all
图片
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All lanes : Anti-GABA B Receptor 2/GABBR2 (phospho S884) antibody [EP2317Y] (ab68425) at 1/5000 dilution
Lane 1 : Untreated Human brain lysate
Lane 2 : AP-treated Human brain lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled Goat anti-Rabbit at 1/2000 dilution
Predicted band size: 106 kDa
Observed band size: 106 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab68425 尚未被引用在任何文献中。