Anti-GABA B Receptor 2 (phospho S783)抗体(ab72447)


  • 产品名称
    Anti-GABA B Receptor 2 (phospho S783)抗体
    参阅全部 GABA B Receptor 2 一抗
  • 描述
    兔多克隆抗体to GABA B Receptor 2 (phospho S783)
  • 宿主
  • 特异性
    ab72447 recognises GABA B Receptor 2 when phosphorylated at Ser 783.
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Chicken, Cow, Human, Xenopus laevis, Non human primates
  • 免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of rat GABA B Receptor 2.

  • 阳性对照
    • rat synaptic membrane



Our Abpromise guarantee covers the use of ab72447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
ICC/IF 1/500.


  • 功能
    Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
  • 组织特异性
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
  • 序列相似性
    Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • 结构域
    Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.
  • 细胞定位
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BcDNA:GH07312 antibody
    • CG6706 antibody
    • CT20836 antibody
    • D Gaba2 antibody
    • FLJ36928 antibody
    • G protein coupled receptor 51 antibody
    • G-protein coupled receptor 51 antibody
    • GAB B R2 antibody
    • GABA B R2 antibody
    • GABA B receptor 2 antibody
    • GABA-B receptor 2 antibody
    • GABA-B-R2 antibody
    • GABA-BR2 antibody
    • GABAB R2 antibody
    • GABABR 2 antibody
    • GABABR2 antibody
    • GABB R2 antibody
    • GABBR 2 antibody
    • Gabbr2 antibody
    • GABR2_HUMAN antibody
    • Gamma aminobutyric acid B receptor 2 antibody
    • Gamma aminobutyric acid GABA B receptor 2 antibody
    • Gamma aminobutyric acid type B receptor subunit 2 antibody
    • Gamma-aminobutyric acid type B receptor subunit 2 antibody
    • Gb 2 antibody
    • Gb2 antibody
    • GH07312 antibody
    • GPR 51 antibody
    • GPR51 antibody
    • GPRC 3B antibody
    • GPRC3B antibody
    • HG 20 antibody
    • HG20 antibody
    • HRIHFB2099 antibody
    • Metabotropic GABA B receptor subtype 2 antibody
    • OTTHUMP00000021776 antibody
    • OTTHUMP00000063797 antibody
    • R2 SUBUNIT antibody
    see all


  • All lanes : Anti-GABA B Receptor 2 (phospho S783) antibody (ab72447) at 1/1000 dilution

    Lane 1 : rat synaptic membrane
    Lane 2 : rat synaptic membrane pre-incubated in lambda-Phosphatase (1200 units
    for 30 min)

    Predicted band size: 106 kDa
    Observed band size: 106 kDa

    The immunolabeling is completely eliminated by treatment with lambda Ptase.


ab72447 has not yet been referenced specifically in any publications.


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