Anti-GABA A Receptor gamma 2抗体- Extracellular domain (ab49961)

概述

  • 产品名称Anti-GABA A Receptor gamma 2抗体- Extracellular domain
    参阅全部 GABA A Receptor gamma 2 一抗
  • 描述
    兔多克隆抗体to GABA A Receptor gamma 2 - Extracellular domain
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
    预测可用于: Chicken
  • 免疫原

    Synthetic peptide:

    QKSDDDYEDYASNKT(C)

    , corresponding to N terminal amino acids 40-54 of rat GABA A Receptor gamma 2

  • 阳性对照
    • Rat brain membrane extracts and rat brain formalin-fixed frozen sections

性能

应用

Our Abpromise guarantee covers the use of ab49961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-Fr
  • 应用说明IHC-Fr: Use at an assay dependent dilution.
    Note: use paraformaldehyde as fixative
    WB: 1/200. Predicted molecular weight: 54 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    • 疾病相关Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions.
      Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8) [MIM:611277]. A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients.
      Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
      Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus.
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
    • 翻译后修饰Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.
    • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAE 2 antibody
      • CAE2 antibody
      • ECA 2 antibody
      • ECA2 antibody
      • GABA(A) receptor gamma 2 antibody
      • GABA(A) receptor subunit gamma 2 antibody
      • GABA(A) receptor subunit gamma-2 antibody
      • GABRG 2 antibody
      • GABRG2 antibody
      • Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody
      • Gamma aminobutyric acid A receptor gamma 2 antibody
      • Gamma aminobutyric acid receptor gamma 2 subunit antibody
      • Gamma-aminobutyric acid receptor subunit gamma-2 antibody
      • GBRG2_HUMAN antibody
      • GEFSP 3 antibody
      • GEFSP3 antibody
      see all

    Anti-GABA A Receptor gamma 2 antibody - Extracellular domain (ab49961)参考文献

    ab49961 has not yet been referenced specifically in any publications.

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