Anti-GABA A Receptor gamma 2抗体(ab16213)

概述

  • 产品名称Anti-GABA A Receptor gamma 2抗体
    参阅全部 GABA A Receptor gamma 2 一抗
  • 描述
    兔多克隆抗体to GABA A Receptor gamma 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Fusion protein corresponding to Rat GABA A Receptor gamma 2.

性能

应用

Our Abpromise guarantee covers the use of ab16213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 44 kDa.

靶标

  • 功能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 疾病相关Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions.
    Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8) [MIM:611277]. A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients.
    Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
  • 翻译后修饰Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAE 2 antibody
    • CAE2 antibody
    • ECA 2 antibody
    • ECA2 antibody
    • GABA(A) receptor gamma 2 antibody
    • GABA(A) receptor subunit gamma 2 antibody
    • GABA(A) receptor subunit gamma-2 antibody
    • GABRG 2 antibody
    • GABRG2 antibody
    • Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody
    • Gamma aminobutyric acid A receptor gamma 2 antibody
    • Gamma aminobutyric acid receptor gamma 2 subunit antibody
    • Gamma-aminobutyric acid receptor subunit gamma-2 antibody
    • GBRG2_HUMAN antibody
    • GEFSP 3 antibody
    • GEFSP3 antibody
    see all

Anti-GABA A Receptor gamma 2 antibody 图像



  • Predicted band size : 44 kDa
    Rat hippocampal lysate

Anti-GABA A Receptor gamma 2 antibody (ab16213)参考文献

This product has been referenced in:
  • Lee V  et al. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus 26:1276-90 (2016). Read more (PubMed: 27163381) »
  • Almeida-Suhett CP  et al. Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury. PLoS One 9:e102627 (2014). WB ; Rat . Read more (PubMed: 25047645) »

See all 3 Publications for this product

Product Wall

Thank you for contacting us. I am sorry to hear that ab16213 is not giving any signal in WB.

The protocol you are using seems fine. One thing you may want to check would be whether your transfer is efficient at higher molecular weights (250-3...

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