Anti-GABA A Receptor delta抗体[S151-3] (ab93619)

概述

  • 产品名称Anti-GABA A Receptor delta抗体[S151-3]
    参阅全部 GABA A Receptor delta 一抗
  • 描述
    小鼠单克隆抗体[S151-3] to GABA A Receptor delta
  • 特异性GABA A receptor delta
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Cow
  • 免疫原

    Synthetic peptide:

    CTQPHHGARAMNDIGDYVGSN

    , corresponding to amino acids 15-34 of Rat GABA A Receptor delta

  • 阳性对照
    • Rat brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab93619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ICC
  • 应用说明ICC: Use at a concentration of 0.1 - 1 µg/ml.
    WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 51 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    • 疾病相关Defects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
      Defects in GABRD are the cause of susceptibility to idiopathic generalized epilepsy type 10 (IGE10) [MIM:613060]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
      Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7) [MIM:613060]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.
    • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • GABA(A) receptor subunit delta antibody
      • Gabrd antibody
      • Gamma aminobutyric acid GABA A receptor delta antibody
      • Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody
      • Gamma-aminobutyric acid receptor subunit delta antibody
      • GBRD_HUMAN antibody
      • MGC45284 antibody
      see all

    Anti-GABA A Receptor delta antibody [S151-3] (ab93619)参考文献

    ab93619 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunohistochemistry (PFA perfusion fixed frozen sections)
    Sample Rat Tissue sections (Brain)
    Antigen retrieval step None
    Permeabilization No
    Specification Brain
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 24°C
    Fixative Paraformaldehyde
    Username

    Mrs. Olga Cravetchi

    Verified customer

    提交于 Jul 12 2016

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"