Anti-GABA A Receptor beta 2抗体(ab8340)

概述

  • 产品名称
    Anti-GABA A Receptor beta 2抗体
    参阅全部 GABA A Receptor beta 2 一抗
  • 描述
    兔多克隆抗体to GABA A Receptor beta 2
  • 经测试应用
    适用于: IP, WBmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Fusion protein of MBP with the amino acid sequence representing the cytosolic loop of the rat GABA-A receptor beta 2 subunit.

性能

应用

Our Abpromise guarantee covers the use of ab8340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution. Use 15µg for 150 µl tissue (68% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains).
WB 1/1000. By Western blot, this antibody detects an 50 - 53 kDa protein, corresponding to the expected molecular weight of GABA A receptor beta 2 subunit.

靶标

  • 功能
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 组织特异性
    Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
  • 序列相似性
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
  • 细胞定位
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GABA antibody
    • GABA(A) receptor beta 2 antibody
    • GABA(A) receptor subunit beta-2 antibody
    • GABA-A receptor, beta-2 polypeptide antibody
    • GABRB2 antibody
    • Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody
    • Gamma aminobutyric acid A receptor beta 2 antibody
    • Gamma-aminobutyric acid receptor subunit beta-2 antibody
    • Gamma-aminobutyric-acid receptor subunit beta-2 antibody
    • GBRB2_HUMAN antibody
    see all

文献

This product has been referenced in:
  • Jovasevic V  et al. GABAergic mechanisms regulated by miR-33 encode state-dependent fear. Nat Neurosci 18:1265-71 (2015). Read more (PubMed: 26280760) »
  • Bates RC  et al. Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience 273:52-64 (2014). Read more (PubMed: 24836856) »

See all 3 Publications for this product

客户评价及客户问答

Thank you for the response.

I am very glad that your customer accepts my offer to give ab123288 Anti-GABA A Receptor beta 2 antibodya try. However, can you confirm that theab8340 was on order PO-12345, Abcam reference123456?

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Thank you for your reply.

I am sorry that we are not able to provide the sequence in this particular case. We are aware that this is not an ideal situation.Although we are providing the immunogen in many cases, this is not true in these circu...

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Thank you for your inquiry.

Unfortunately, we are not able to release the immunogen sequence for these particular antibodies as it is proprietary information. Unfortunately, we do not have the corresponding peptides for sale, either.
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Je suis ravie que vous souhaitiez participer a notre offre et tester ab8340 sur coupes paraffines (IHC-P). Le code de réduction correspondant est xx. Ce code de réduction est utilisable sous 120 jours et pour l’achat d’un autre anticorps pri...

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Thank you for your enquiry. The lysate used to characterize both ab8340 (NB 300-198) and ab8341( NB 300-148) was rat brain (hippocampal) lysate using approximately 5-7 micrograms of tissue per slot. If you have any additional questions, please contact ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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