Anti-GABA A Receptor alpha 6抗体(ab117100)

概述

  • 产品名称
    Anti-GABA A Receptor alpha 6抗体
    参阅全部 GABA A Receptor alpha 6 一抗
  • 描述
    山羊多克隆抗体to GABA A Receptor alpha 6
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    HPDSKYHLKKR

    with a Cysteine residue linker, corresponding to internal sequence amino acids 363-373 of Human GABA A Receptor alpha 6 (NP_000802.2).

  • 阳性对照
    • Human brain (cortex) tissue; Human cerebellum lysate.

性能

应用

Our Abpromise guarantee covers the use of ab117100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 51 kDa.
ELISA Use a concentration of 1 - 3 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 序列相似性
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.
  • 细胞定位
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GABA A antibody
    • GABA A Receptor alpha 6 polypeptide antibody
    • GABA A receptor alpha 6 antibody
    • GABA A receptor subunit alpha 6 antibody
    • GABA subunit A receptor alpha 6 antibody
    • GABA(A) receptor subunit alpha-6 antibody
    • GABRA 6 antibody
    • GABRA6 antibody
    • Gamma aminobutyric acid A receptor alpha 6 antibody
    • Gamma aminobutyric acid GABA A receptor alpha 6 antibody
    • Gamma aminobutyric acid receptor subunit alpha 6 antibody
    • Gamma-aminobutyric acid receptor subunit alpha-6 antibody
    • GBRA6_HUMAN antibody
    • MGC116903 antibody
    • MGC116904 antibody
    see all

Anti-GABA A Receptor alpha 6 antibody 图像

  • Anti-GABA A Receptor alpha 6 antibody (ab117100) at 1 µg/ml + Human cerebellum lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 51 kDa
  • ab117100 at 2.5ug/ml staining GABA A Receptor alpha 6 in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-GABA A Receptor alpha 6 antibody (ab117100)参考文献

This product has been referenced in:
  • Kaneko Y  et al. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci Rep 6:35659 (2016). WB ; Rat . Read more (PubMed: 27767042) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Hippocampus and Cerebellum)
Permeabilization
No
Specification
Hippocampus and Cerebellum
Fixative
Paraformaldehyde
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提交于 Jun 30 2017

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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