Anti-GABA A Receptor alpha 2/GABRA2抗体(ab72445)
Key features and details
- Rabbit polyclonal to GABA A Receptor alpha 2/GABRA2
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-GABA A Receptor alpha 2/GABRA2抗体
参阅全部 GABA A Receptor alpha 2/GABRA2 一抗 -
描述
兔多克隆抗体to GABA A Receptor alpha 2/GABRA2 -
宿主
Rabbit -
特异性
ab72445 is specific for GABA A Receptor alpha 2/GABRA2
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse
预测可用于: Cow, Dog, Human, Non human primates, Zebrafish -
免疫原
Fusion protein. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- rat brain lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.50
Constituents: 0.01% BSA, 50% Glycerol, 0.87% Sodium chloride, 0.238% HEPES -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab72445于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
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说明 |
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WB
1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa). |
靶标
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功能
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. -
序列相似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. -
细胞定位
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 282236 Cow
- Entrez Gene: 2555 Human
- Entrez Gene: 14395 Mouse
- Omim: 137140 Human
- SwissProt: P10063 Cow
- SwissProt: P47869 Human
- SwissProt: P26048 Mouse
- Unigene: 116250 Human
see all -
别名
- GABA A receptor subunit alpha 2 antibody
- GABA antibody
- GABA(A) receptor subunit alpha 2 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (18)
ab72445 被引用在 18 文献中.
- Zavalin K et al. Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons. Front Mol Neurosci 15:826427 (2022). PubMed: 35370549
- Jeong AH et al. Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models. Int J Mol Sci 22:N/A (2021). PubMed: 33805468
- Al-Absi AR et al. Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability. Mol Neurobiol 57:4978-4988 (2020). PubMed: 32820460
- Hosseini M et al. Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury. Brain Behav 10:e01576 (2020). PubMed: 32189472
- Zhang Y et al. MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning. Elife 9:N/A (2020). PubMed: 32420873