Anti-GABA A Receptor alpha 1抗体(ab32589)

概述

  • 产品名称Anti-GABA A Receptor alpha 1抗体
    参阅全部 GABA A Receptor alpha 1 一抗
  • 描述
    兔多克隆抗体to GABA A Receptor alpha 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat, Cow, Human
  • 免疫原

    Fusion protein from the cytoplasmic loop of the alpha1-subunit of rat GABAA Receptor

  • 阳性对照
    • Rat, bovine, human and mouse brain extracts

性能

应用

Our Abpromise guarantee covers the use of ab32589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).

靶标

  • 功能GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 疾病相关Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood.
    Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5) [MIM:611136]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ECA4 antibody
    • EIEE19 antibody
    • EJM antibody
    • EJM5 antibody
    • Gaba receptor alpha 1 polypeptide antibody
    • GABA(A) receptor antibody
    • GABA(A) receptor subunit alpha 1 antibody
    • GABA(A) receptor subunit alpha-1 antibody
    • GABA(A) receptor, alpha 1 antibody
    • GABRA 1 antibody
    • GABRA1 antibody
    • Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody
    • Gamma aminobutyric acid A receptor alpha 1 antibody
    • Gamma aminobutyric acid receptor subunit alpha 1 antibody
    • Gamma aminobutyric acid type A receptor alpha1 subunit antibody
    • Gamma-aminobutyric acid receptor subunit alpha-1 antibody
    • GBRA1_HUMAN antibody
    see all

Anti-GABA A Receptor alpha 1 antibody 图像

  • All lanes : Anti-GABA A Receptor alpha 1 antibody (ab32589) at 1/1000 dilution

    Lane 1 : Wildtype forebrain lysates 5-7 ug
    Lane 2 : a1 knockout forebrain lysates 5-7 ug


    Predicted band size : 51 kDa
    Observed band size : 51 kDa

Anti-GABA A Receptor alpha 1 antibody (ab32589)参考文献

ab32589 has not yet been referenced specifically in any publications.

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