Anti-GAB1 (phospho Y659)抗体(ab59410)

概述

  • 产品名称Anti-GAB1 (phospho Y659)抗体
    参阅全部 GAB1 一抗
  • 描述
    兔多克隆抗体to GAB1 (phospho Y659)
  • 特异性This antibody detects endogenous levels of GAB1 only when phosphorylated at tyrosine 659. Human: Tyr659; Mouse: Tyr660.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic phosphopeptide derived from human GAB1 around the phosphorylation site of tyrosine 659 (VDYPVV).

  • 阳性对照
    • NIH/3T3 cell extracts

性能

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应用

Our Abpromise guarantee covers the use of ab59410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 77 kDa (predicted molecular weight: 77 kDa).
ELISA 1/5000.

靶标

  • 功能Probably involved in EGF and insulin receptor signaling.
  • 序列相似性Belongs to the GAB family.
    Contains 1 PH domain.
  • 翻译后修饰Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gab 1 antibody
    • GAB1 antibody
    • GAB1_HUMAN antibody
    • GRB 2 associated binder 1 antibody
    • GRB 2 associated binding protein 1 antibody
    • GRB2 associated binding protein 1 isoform a antibody
    • GRB2 associated binding protein 1 isoform b antibody
    • GRB2-associated binder 1 antibody
    • GRB2-associated-binding protein 1 antibody
    • Growth factor receptor bound protein 2-associated protein 1 antibody
    see all

Anti-GAB1 (phospho Y659) antibody 图像

  • All lanes : Anti-GAB1 (phospho Y659) antibody (ab59410) at 1/500 dilution

    Lane 1 : NIH/3T3 cells, treated with Insulin (0.01U/ml, 15mins)
    Lane 2 : NIH/3T3 cells, treated with Insulin (0.01U/ml, 15mins) with immunizing phosphopeptide


    Predicted band size : 77 kDa
    Observed band size : 77 kDa

Anti-GAB1 (phospho Y659) antibody (ab59410)参考文献

ab59410 has not yet been referenced specifically in any publications.

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