功能Probably involved in EGF and insulin receptor signaling.
序列相似性Belongs to the GAB family. Contains 1 PH domain.
翻译后修饰Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.
ab32093 at a 1:50 dilution staining GAB1 in PC-12 cells using immunofluoresence
Anti-GAB1 antibody [Y423] (ab32093)参考文献
This product has been referenced in:
Le Goff A et al. Anti-apoptotic Role of Caspase-cleaved GAB1 Adaptor Protein in Hepatocyte Growth Factor/Scatter Factor-MET Receptor Protein Signaling. J Biol Chem287:35382-96 (2012).
Read more (PubMed: 22915589) »