G Protein alpha Inhibitor 1+2肽(ab5006)

概述

  • 产品名称G Protein alpha Inhibitor 1+2肽

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab5006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human G protein alpha inhibitor 1/2, catalog ab3522. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Adenylate cyclase-inhibiting G alpha protein
    • Gi
    • Gi1 protein alpha subunit
    • Gi2 protein alpha subunit
    • GIP
    • GNAI1
    • GNAI1_HUMAN
    • GNAI2
    • GNAI2B
    • Guanine nucleotide binding protein G(i) alpha 1 subunit
    • Guanine nucleotide binding protein G(i) alpha 2 subunit
    • Guanine nucleotide-binding protein G(i) subunit alpha-1
    see all
  • 功能Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
  • 序列相似性Belongs to the G-alpha family. G(i/o/t/z) subfamily.
  • 细胞定位Nucleus. Cytoplasm. Cell membrane. Cytoplasm > cytoskeleton > centrosome. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody.
  • Information by UniProt

G Protein alpha Inhibitor 1+2 peptide (ab5006)参考文献

ab5006 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"