概述

  • 产品名称Anti-FZD3抗体
    参阅全部 FZD3 一抗
  • 描述
    小鼠单克隆抗体to FZD3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 55-158 of Human FZD3

性能

应用

Our Abpromise guarantee covers the use of ab56331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 组织特异性Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
    • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 细胞定位Membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Frizzled 3 antibody
      • Frizzled 3 seven transmembrane spanning receptor antibody
      • Frizzled family receptor 3 antibody
      • Frizzled homolog 3 (Drosophila) antibody
      • Frizzled homolog 3 antibody
      • Frizzled-3 antibody
      • Frizzled3 antibody
      • Fz 3 antibody
      • Fz-3 antibody
      • Fz3 antibody
      • FZD 3 antibody
      • Fzd3 antibody
      • FZD3_HUMAN antibody
      • hFz 3 antibody
      • hFz3 antibody
      see all

    Anti-FZD3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56331 FZD3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-FZD3 antibody (ab56331)参考文献

    This product has been referenced in:
    • Valastyan S  et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137:1032-46 (2009). WB ; Human . Read more (PubMed: 19524507) »

    See 1 Publication for this product

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