概述

  • 产品名称
  • 描述
    兔多克隆抗体to Fyn
  • 经测试应用
    适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH-conjugated synthetic peptide, from the N-terminal region of Human Fyn

  • 阳性对照
    • Mouse liver lysate; Human breast carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab71676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Predicted molecular weight: 60 kDa.

靶标

  • 功能
    Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3.
  • 组织特异性
    Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 细胞定位
    Cell membrane. Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
  • Information by UniProt
  • 数据库链接
  • 形式
    This protein is known to be similar in amino acid sequence to HCK (P08631), LCK (P06239), YES1 (P07947), SRC (P12931), and LYN (P07948). Therefore, cross-reactivity with these homologous proteins may be observed. We would be happy to provide immunogen alignment information upon request.
  • 别名
    • C syn protooncogene antibody
    • Fyn antibody
    • FYN oncogene related to SRC FGR YES antibody
    • FYN_HUMAN antibody
    • OKT3 induced calcium influx regulator antibody
    • P59 FYN antibody
    • p59-Fyn antibody
    • Protein tyrosine kinase fyn antibody
    • Proto oncogene tyrosine protein kinase fyn antibody
    • Proto-oncogene c-Fyn antibody
    • Proto-oncogene Syn antibody
    • Protooncogene Syn antibody
    • SLK antibody
    • Src like kinase antibody
    • Src yes related novel gene antibody
    • Src-like kinase antibody
    • Src/yes related novel antibody
    • SYN antibody
    • Tyrosine kinase p59fyn T antibody
    • Tyrosine kinase p59fyn(T) antibody
    • Tyrosine-protein kinase Fyn antibody
    see all

图片

  • Anti-Fyn antibody (ab71676) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg

    Secondary
    Secondary HRP-anti-rabbit

    Predicted band size : 60 kDa
    Observed band size : 60 kDa
    Additional bands at : 65 kDa. We are unsure as to the identity of these extra bands.
  • Analysis of Fyn expression on formalin-fixed and paraffin-embedded human breast carcinoma tissue using 1:100 ab71676 (peroxidase-conjugated secondary antibody, DAB staining).

文献

This product has been referenced in:
  • Aonurm-Helm A  et al. NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice. Brain Res 1309:1-8 (2010). WB ; Mouse . Read more (PubMed: 19909731) »

See 1 Publication for this product

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