概述

  • 产品名称Anti-FXC1抗体
    参阅全部 FXC1 一抗
  • 描述
    小鼠单克隆抗体to FXC1
  • 经测试应用适用于: WB, ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 11-104 of Human FXC1 with a proprietary tag (NP_036324).

  • 阳性对照
    • Recombinant Protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 12 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

靶标

  • 功能Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
  • 组织特异性Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
  • 序列相似性Belongs to the small Tim family.
  • 结构域The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of FXC1/TIM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fracture callus 1 homolog (rat) antibody
    • Fracture callus 1 homolog antibody
    • Fracture callus protein 1 antibody
    • FxC1 antibody
    • Mitochondrial import inner membrane translocase subunit Tim10 B antibody
    • Mitochondrial import inner membrane translocase subunit Tim9 B antibody
    • OTTHUMP00000164584 antibody
    • OTTHUMP00000230720 antibody
    • TIM 10B antibody
    • Tim10b antibody
    • Tim9b antibody
    • TIM9B_HUMAN antibody
    • TIMM10B antibody
    • Translocase of inner mitochondrial membrane 10 homolog B (yeast) antibody
    see all

Anti-FXC1 antibody 图像

  • Anti-FXC1 antibody (ab118117) at 5 µg/ml + Recombinant immunogen at 0.2 µg
    Developed using the ECL technique

    Predicted band size : 12 kDa
  • ab118117 at 10 µg/ml as a capture antibody. The detection limit for recombinant tagged FXC1 is 0.03 ng/ml.

Anti-FXC1 antibody (ab118117)参考文献

ab118117 has not yet been referenced specifically in any publications.

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