概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab4989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and furin convertase, catalog ab3467. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • Dibasic processing enzyme
    • Dibasic-processing enzyme
    • FES upstream region
    • FUR
    • FURIN
    • Furin membrane associated receptor protein
    • FURIN_HUMAN
    • PACE
    • Paired basic amino acid residue cleaving enzyme
    • Paired basic amino acid residue-cleaving enzyme
    • PCSK3
    • Proprotein convertase subtilisin/kexin type 3
    • SPC1
    see all
  • 功能Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
  • 组织特异性Seems to be expressed ubiquitously.
  • 序列相似性Belongs to the peptidase S8 family. Furin subfamily.
    Contains 1 homo B/P domain.
  • 结���域Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
  • 翻译后修饰The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
    Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.
  • 细胞定位Golgi apparatus > trans-Golgi network membrane. Cell membrane. Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
  • Information by UniProt

Furin peptide (ab4989)参考文献

ab4989 has not yet been referenced specifically in any publications.

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