Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
A synthetic peptide corresponding to a region of Human FUNDC1
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 2% Sucrose, PBS
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||Use a concentration of 1 µg/ml. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
||Use at an assay dependent concentration.
ELISA titre using peptide based assay: 1:1562500.
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Belongs to the FUN14 family.
The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP (PubMed:22267086).
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.
Mitochondrion outer membrane.
Information by UniProt
- FUN14 domain containing 1 antibody
- FUN14 domain containing protein 1 antibody
- FUN14 domain-containing protein 1 antibody
has not yet been referenced specifically in any publications.
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