Anti-FSTL3抗体[RM0080-7D11] (ab86055)
Key features and details
- Rat monoclonal [RM0080-7D11] to FSTL3
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
概述
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产品名称
Anti-FSTL3抗体[RM0080-7D11]
参阅全部 FSTL3 一抗 -
描述
大鼠单克隆抗体[RM0080-7D11] to FSTL3 -
宿主
Rat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Mouse recombinant FSTL3.
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阳性对照
- WB: Mouse embryonic tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography filtered sterilized. -
克隆
单克隆 -
克隆编号
RM0080-7D11 -
同种型
IgG2 -
研究领域
相关产品
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab86055于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 28 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 28 kDa. |
靶标
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功能
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. -
组织特异性
Expressed in a wide range of tissues. -
疾病相关
Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. -
序列相似性
Contains 2 follistatin-like domains.
Contains 2 Kazal-like domains.
Contains 1 TB (TGF-beta binding) domain. -
细胞定位
Secreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. - Information by UniProt
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数据库链接
- Entrez Gene: 83554 Mouse
- SwissProt: Q9EQC7 Mouse
- Unigene: 251710 Mouse
- Unigene: 490276 Mouse
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别名
- FLRG antibody
- follistatin-like 3 antibody
- follistatin-like 3 glycoprotein antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab86055 尚未被引用在任何文献中。