概述

  • 产品名称Anti-FSH Receptor抗体
    参阅全部 FSH Receptor 一抗
  • 描述
    兔多克隆抗体to FSH Receptor
  • 特异性Detects endogenous levels of total FSH Receptor protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal region of human FSH Receptor

  • 阳性对照
    • Transfected Jurkat and HUVEC cell extracts

性能

应用

Our Abpromise guarantee covers the use of ab75200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 78 kDa.
ELISA 1/5000.

靶标

  • 功能Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • 组织特异性Sertoli cells and ovarian granulosa cells.
  • 疾病相关Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
    Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • 翻译后修饰N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Follicle stimulating hormone receptor antibody
    • Follicle stimulating hormone receptor isoform 1 antibody
    • Follicle-stimulating hormone receptor antibody
    • Follitropin receptor antibody
    • FSH receptor antibody
    • FSH-R antibody
    • Fshr antibody
    • FSHR_HUMAN antibody
    • FSHRO antibody
    • LGR1 antibody
    • MGC141667 antibody
    • MGC141668 antibody
    • ODG1 antibody
    • ovarian dysgenesis 1 antibody
    see all

Anti-FSH Receptor antibody 图像

  • All lanes : Anti-FSH Receptor antibody (ab75200) at 1/500 dilution

    Lane 1 : Transfected Jurkat cell extract
    Lane 2 : Transfected HUVEC cell extract
    Lane 3 : Transfected Jurkat cell extract with immunising peptide at 10 µg

    Lysates/proteins at 10 µg per lane.


    Predicted band size : 78 kDa
    Observed band size : 78 kDa
    Additional bands at : 85 kDa. We are unsure as to the identity of these extra bands.

Anti-FSH Receptor antibody (ab75200)参考文献

This product has been referenced in:
  • Sen A  et al. Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression. Proc Natl Acad Sci U S A 111:3008-13 (2014). Read more (PubMed: 24516121) »
  • Robinson LJ  et al. FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts. Biochem Biophys Res Commun 394:12-7 (2010). WB ; Human . Read more (PubMed: 20171950) »

See all 2 Publications for this product

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