Anti-Frizzled homolog 1抗体(ab75201)


  • 产品名称Anti-Frizzled homolog 1抗体
    参阅全部 Frizzled homolog 1 一抗
  • 描述
    兔多克隆抗体to Frizzled homolog 1
  • 特异性Detects endogenous levels of total Frizzled homolog 1 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an N-terminal region of human Frizzled homolog 1.

  • 阳性对照
    • Jurkat cell extract



Our Abpromise guarantee covers the use of ab75201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 71 kDa.
ELISA 1/5000.


  • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
  • 组织特异性Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
  • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chfz-1 antibody
    • Dfrizzled-1 antibody
    • DKFZp564G072 antibody
    • FLJ95923 antibody
    • Frizzled 1 antibody
    • Frizzled homolog 1 (Drosophila) antibody
    • Frizzled homolog 1 antibody
    • Frizzled-1 antibody
    • Fz receptor 1 antibody
    • Fz-1 antibody
    • Fz1 antibody
    • FZD1 antibody
    • FZD1_HUMAN antibody
    • FzE1 antibody
    • hFz1 antibody
    • Rfz1 antibody
    • Wnt receptor antibody
    • Xfrizzled-1 antibody
    see all

Anti-Frizzled homolog 1 antibody 图像

  • All lanes : Anti-Frizzled homolog 1 antibody (ab75201) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : Jurkat cell extract with immunising peptide at 10 µg

    Lysates/proteins at 10 µg per lane.

    Predicted band size : 71 kDa
    Observed band size : 71 kDa
    Additional bands at : 90 kDa. We are unsure as to the identity of these extra bands.

Anti-Frizzled homolog 1 antibody (ab75201)参考文献

ab75201 has not yet been referenced specifically in any publications.

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