Anti-Frizzled homolog 1抗体(ab117305)


  • 产品名称Anti-Frizzled homolog 1抗体
    参阅全部 Frizzled homolog 1 一抗
  • 描述
    兔多克隆抗体to Frizzled homolog 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Dog, Chimpanzee, Macaque Monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Human Frizzled homolog 1.

  • 阳性对照
    • This antibody gave a positive signal in the following Human tissue lysates: Heart; Placenta; Lung; Kidney; Pancreas.



Our Abpromise guarantee covers the use of ab117305 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 71 kDa (predicted molecular weight: 71 kDa).


  • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
  • 组织特异性Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
  • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chfz-1 antibody
    • Dfrizzled-1 antibody
    • DKFZp564G072 antibody
    • FLJ95923 antibody
    • Frizzled 1 antibody
    • Frizzled homolog 1 (Drosophila) antibody
    • Frizzled homolog 1 antibody
    • Frizzled-1 antibody
    • Fz receptor 1 antibody
    • Fz-1 antibody
    • Fz1 antibody
    • FZD1 antibody
    • FZD1_HUMAN antibody
    • FzE1 antibody
    • hFz1 antibody
    • Rfz1 antibody
    • Wnt receptor antibody
    • Xfrizzled-1 antibody
    see all

Anti-Frizzled homolog 1 antibody 图像

  • All lanes : Anti-Frizzled homolog 1 antibody (ab117305) at 1 µg/ml

    Lane 1 : Human heart tissue lysate - total protein (ab29431)
    Lane 2 : Human placenta tissue lysate - total protein (ab29745)
    Lane 3 : Lung (Human) Tissue Lysate
    Lane 4 : Human kidney tissue lysate - total protein (ab30203)
    Lane 5 : Human pancreas tissue lysate - total protein (ab29816)

    Lysates/proteins at 10 µg per lane.

    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 71 kDa
    Observed band size : 71 kDa
    Additional bands at : 40 kDa,47 kDa,88 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 6 minutes

Anti-Frizzled homolog 1 antibody (ab117305)参考文献

ab117305 has not yet been referenced specifically in any publications.

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