RabMAb

Anti-Frizzled 9抗体[EPR4011] (ab108628)

概述

  • 产品名称Anti-Frizzled 9抗体[EPR4011]
    参阅全部 Frizzled 9 一抗
  • 描述
    兔单克隆抗体[EPR4011] to Frizzled 9
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human Frizzled 9.

  • 阳性对照
    • Human seminoma, fetal kidney and fetal testis lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab108628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 65 kDa (predicted molecular weight: 64 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 组织特异性Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
    • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 349 antibody
      • CD 349 antigen antibody
      • CD349 antibody
      • Frizzled Drosophila homolog of 3 antibody
      • Frizzled homolog 9 (Drosophila) antibody
      • Frizzled homolog 9 antibody
      • Frizzled-9 antibody
      • Fz 9 antibody
      • Fz-9 antibody
      • FZD 3 antibody
      • Fzd 9 antibody
      • FZD3 antibody
      • FZD3-PEN antibody
      • FZD9 antibody
      • FZD9_HUMAN antibody
      • FzE6 antibody
      • hFz9 antibody
      • mfz9 antibody
      • Xfz9 antibody
      see all

    Anti-Frizzled 9 antibody [EPR4011] 图像

    • All lanes : Anti-Frizzled 9 antibody [EPR4011] (ab108628) at 1/1000 dilution

      Lane 1 : Human Seminoma lysate
      Lane 2 : Human fetal kidney lysate
      Lane 3 : Human fetal testis lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 64 kDa
      Observed band size : 65 kDa (why is the actual band size different from the predicted?)

    Anti-Frizzled 9 antibody [EPR4011] (ab108628)参考文献

    ab108628 has not yet been referenced specifically in any publications.

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