Anti-Frizzled 9抗体[EPR4011] (ab108628)


  • 产品名称Anti-Frizzled 9抗体[EPR4011]
    参阅全部 Frizzled 9 一抗
  • 描述
    兔单克隆抗体[EPR4011] to Frizzled 9
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human Frizzled 9.

  • 阳性对照
    • Human seminoma, fetal kidney and fetal testis lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab108628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 65 kDa (predicted molecular weight: 64 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    • 组织特异性Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
    • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 结构域Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
      The FZ domain is involved in binding with Wnt ligands.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 349 antibody
      • CD 349 antigen antibody
      • CD349 antibody
      • Frizzled Drosophila homolog of 3 antibody
      • Frizzled homolog 9 (Drosophila) antibody
      • Frizzled homolog 9 antibody
      • Frizzled-9 antibody
      • Fz 9 antibody
      • Fz-9 antibody
      • FZD 3 antibody
      • Fzd 9 antibody
      • FZD3 antibody
      • FZD3-PEN antibody
      • FZD9 antibody
      • FZD9_HUMAN antibody
      • FzE6 antibody
      • hFz9 antibody
      • mfz9 antibody
      • Xfz9 antibody
      see all

    Anti-Frizzled 9 antibody [EPR4011] 图像

    • All lanes : Anti-Frizzled 9 antibody [EPR4011] (ab108628) at 1/1000 dilution

      Lane 1 : Human Seminoma lysate
      Lane 2 : Human fetal kidney lysate
      Lane 3 : Human fetal testis lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 64 kDa
      Observed band size : 65 kDa (why is the actual band size different from the predicted?)

    Anti-Frizzled 9 antibody [EPR4011] (ab108628)参考文献

    ab108628 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab108628.
    Please use the links above to contact us or submit feedback about this product.