Frizzled 8肽(684-694) (ab45837)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-SYPKQMPLSQV
    • 氨基酸684 to 694

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Frizzled 8 antibody (ab40012)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • Frizzled 8 seven transmembrane spanning receptor
    • frizzled 8, seven transmembrane spanning receptor
    • Frizzled family receptor 8
    • Frizzled homolog 8
    • frizzled homolog 8 (Drosophila)
    • Frizzled-8
    • FZ 8
    • Fz-8
    • FZ8
    • FZD 8
    • FZD8
    • FZD8_HUMAN
    • hFZ 8
    • hFz8
    • HGNC4046
    • Homolog of Drosophila Frizzled 8
    see all
  • 功能Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
  • 组织特异性Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
  • 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 结构域The PDZ-binding motif mediates interaction with GOPC.
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
    The FZ domain is involved in binding with Wnt ligands.
  • 翻译后修饰Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • 细胞定位Membrane. Golgi apparatus. Cell membrane. Colocalizes with GOPC at the Golgi apparatus.
  • Information by UniProt

Frizzled 8 peptide (684-694) (ab45837)参考文献

ab45837 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45837.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"